Kelsey Armeni's Co-Authored Paper Published in BMJ Open with the People, Place, and Health Collective at Brown University School of Public Health
Kelsey Armeni's (Cultural Anthropology, PhD in Progress) co-authored paper published in BMJ Open with the People, Place, and Health Collective at Brown University School of Public Health. ÌýThis protocol paper was published for a clinical trial comparing the effectiveness of a high (24 mg) vs standard (16 mg) maintenance daily dose of buprenorphine for opioid use disorder in the era of fentanyl in the unregulated drug supply.Ìý
Abstract
Introduction Buprenorphine is a highly effective treatment for opioid use disorder (OUD). However, provider observations and preliminary research suggest that the current standard maintenance dose may be insufficient for suppressing withdrawal and preventing cravings among people who use or have used fentanyl. Buprenorphine dosing guidelines were based on studies among people who use heroin and have not been formally re-evaluated since fentanyl became predominant in the unregulated drug supply. We aim to compare the effectiveness of a high (24 mg) vs standard (16 mg) maintenance daily dose of buprenorphine for improving retention in treatment, decreasing the use of non-prescribed opioids, preventing cravings and reducing opioid overdose risk in patients.
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